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Chunk #98 — Online Methods — Sharing by sign and magnitude.

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Flexible statistical methods for estimating and testing effects in genomic studies with multiple conditions.
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In Fig. 6 (and Supplementary Fig. 5), we investigate sharing between each pair of tissues. When computing sharing between tissues r and s, we consider only QTLs that are “significant” (lfsr < 0.05) in at least one of r and s. This is to avoid sharing estimates being driven by estimates of null or nearly-null effects.