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Chunk #14 — 2. Materials and Methods — 2.4. MRI Data Acquisition

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Differentiating Individuals with and without Alcohol Use Disorder Using Resting-State fMRI Functional Connectivity of Reward Network, Neuropsychological Performance, and Impulsivity Measures.
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The details of fMRI data acquisition on the same sample have been described previously by our group [63]. Briefly, MRI scanning was performed at the Nathan Kline Institute using a 3.0 Tesla Siemens Tim Trio scanner (Erlangen, Germany). The resting-state fMRI data, used in the current study, were collected during eyes closed alert state for 6.11 s. A series of T2*-weighted gradient echo single-shot echo-planar imaging (EPI) volumes with the following sequence parameters was acquired: TR = 2750 ms; TE = 30 ms; flip angle = 80°; voxel size = 2.5 × 2.5 × 3.5 mm3; matrix size = 96 × 96; number of slices = 50; number of volumes = 130; FOV = 240 mm; and Grappa acceleration factor = 3. The sequence was carefully optimized to minimize the effects of magnetic susceptibility inhomogeneities (such as distortions and signal dropouts), as well as the effects of mechanical vibrations, which elevate Nyquist ghosting levels. In addition, a magnetization-prepared rapid gradient-echo (MPRAGE) high-resolution three-dimensional T1-weighted structural image served as an anatomical reference for the fMRI data, as well as for the