tau (MAPT) that predispose it to aggregation can cause specific diseases that involve profound neurodegeneration and dementia [17], [18]. Thus, like in other neurodegenerative diseases such as Huntington's disease (HD) and Parkinson's disease, the formation of toxic insoluble aggregates seems to be a key pathogenic step. However, it is not known why these Aβ and tau aggregates accumulate in AD patients nor how they contribute to neuronal dysfunction, particularly for Aβ deposits, which can often be found in the brains of elderly non-demented subjects [19].
