Genotype and allele frequencies were compared between groups using X2 contingency analysis. LD and haplotype frequencies were estimated using the Haploview software. Correction for multiple testing was performed using permutation correction. None of the genotype distributions deviated significantly from those expected by Hardy-Weinberg equilibrium for cases or controls. There were no significant differences in allele, genotype or haplotype frequencies between cases and controls for any of the tested SNPs. Allele frequencies were (cases/controls): rs9825563: 0.513/0.566; rs6280(Ser9Gly): 0.749/0.729; rs7625282: 0.738/0.748; rs16822393: 0.785/0.765; rs167770: 0.605/0.630; rs2630349; 0.660/0.710; rs3773678: 0.651/0.614; rs9824856: 0.671/0.714; rs9817063: 0.632/0.588. Allele frequencies were similar to those published in the HapMap database. There was moderate LD between markers. Power to detect an effect size of 1.5 was moderate to good (0.78-0.86).
