We do not estimate enrichment of psychiatric factors for continuous or flanking window annotations, yielding a total of 168 binary annotations across the baseline model, gene expression, histone marks, PI, and brain cell annotations. For a Bonferroni correction < 0.05, this corresponds to P < 2.98 × 10−4. We note that continuous and flanking window annotations were retained for construction of the genome-wide, S-LDSC matrix.