We compared our CMC DLPFC associations to results using a single-eQTL based method, SMR12, in the PGC+CLOZUK schizophrenia GWAS60, which identified 12 genome-wide significant associations. All significant SMR associations were also significant in our DLPFC prediXcan analysis, and all directions of effect were concordant between the two studies. A recent TWAS study of 30 GWAS summary statistic traits56 identified 38 non-MHC genes associated at tissue-level significance with SCZ in CMC- and GTEx-derived brain tissues (i.e., matching those used in our study). Of these, 26 also reach genome-wide significance in our study, although in many instances these genes are not identified as the lead independent associated gene following our conditional analysis. Among our 67 SCZ-associated genes, 19 were novel, i.e. did not fall within 1 Mb of a previous GWAS locus (including 5/7 of the novel brain genes identified in the recent TWAS analysis).
