Mb 15q25 region by having about 1.5% (~ 4700) of the living population typed. With improved analytical tools (see below), and in some cases focusing on smaller regions, useful results could possibly be obtained with only 1% of the living population genotyped. Based on the fraction of the population typed, we believe that these results would apply, albeit crudely, to populations of various sizes, including large out-bred populations (see Supplementary Note for a discussion of how LRP might work with non-Icelandic data).