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Chunk #0 — INTRODUCTION

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Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20 328 research participants of European ancestry.
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The heritability of AUD and associated symptomatology such as high alcohol consumption has been estimated at ~50% by family and twin studies (Verhulst, Neale & Kendler 2015; Mbarek et al. Vink 2015), with a smaller proportion being attributable to additive effects of common genetic variation (e.g. 33% for AUD (Mbarek et al. 2015); 18% (Vrieze, McGue, Miller, Hicks & Iacono 2013) and 13% (Clarke et al. 2017) for alcohol consumption).