Chunk #18 — Results — Screening System of Drug Permeability with BBB Model

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In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling.

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We also investigated DHA permeability for analyzing the function of the nutrient transporter in our BBB model. An analysis of DHA kinetics with nanoLC-MS/MS showed that ciBECs significantly increased the permeability of DHA compared with ECs (Figure S5D). This result suggested that nutrient transporters such as MFSD2A in hiPSC-derived ciBECs are functional in the BBB model.