Chunk #29 — GABRG1 haplotype associations — Plains Indians — Long-distance haplotypes across GABRG1 – GABRA2: influence of GABRA2 on association with AUD
In the Finns, the variant alleles of these two GABRG1 SNPs were found on three extended haplotypes (total frequency = 0.06) that only differed in the GABRA2 block 2 SNPs: haplotypes 22111221121122 (0.01); 22111221121211 (0.02); and 22111221121222 (0.03). These haplotypes differed in their association with AUD. Two haplotypes were more common in alcoholics than in non-alcoholics: 22111221121122 (0.29 vs 0.12) and 22111221121222 (0.57 vs 0.44). In contrast, 22111221121211 was more common in non-alcoholics compared with alcoholics (0.44 vs 0.14); χ2 = 6.8, 2 df, p = 0.034.
