Elucidating the genetic control of biological processes is a critical issue in the post genome era. This will inform on the basic biological level and lead to clearer understanding of the pathophysiology underlying human disease. The work we have described here and the public release of the data resulting from this effort, aims to facilitate an understanding of the initial consequences of common genetic variation on DNA methylation and gene expression in brain (GEO Accession Number: GSE15745; dbGAP Study Accession: phs000249.v1.p1) [20]–[22].