risk to the other psychiatric disorders investigated were found to influence depression (range 87-99%; Figure 2; Supplementary Table S6A), most pronounced for anxiety, schizophrenia, bipolar disorder and ADHD47 with 95-99% of their risk variants also influencing depression. The other correlated traits also showed substantial overlap with depression (range 87-97%), while height and Alzheimer’s disease did not. We note that nearly all (99%) of the depression risk variants were found to influence educational attainment. The fraction of variants affecting both traits in the same (concordant) direction varied considerably; lowest for educational attainment (42%) and highest for SUD (86%) and anxiety (89%).
