Other benzodiazepine site ligands, such as the imidazobenzodiazepines flumazenil or Ro15-4513, are also able to interact with α4βγ2 or α6βγ2 receptors. These drugs have been used for identification of these receptor subtypes in the brain with ligand binding studies and autoradiography, using [3H]Ro15-4513 in the absence, or presence, of high concentrations of diazepam or flumazenil, to mask receptors containing the α1, α2, α3, or α5 subunits. (Korpi et al., 2002).
