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Chunk #5 — Methods and Materials — Cis-eQTL mapping using human prefrontal cortex in the BrainCloud cohort

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Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1.
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To identify putative cis-eQTL SNPs for OPRM1, we utilized SNP genotype and gene expression data (see Supplement) available on post-mortem dorsolateral prefrontal cortex samples from 110 European Americans and 114 African Americans, ranging in age from 0 to 78 years old, who had no neuropathological or neuropsychiatric diagnoses, no drug or alcohol abuse, and no positive toxicology result (32-34).