Accordingly, we present herein the results of a case–control association study in a sample of 1,085 unrelated women with a lifetime history of AN and 677 unrelated controls ascertained in the multisite Price Foundation Genetic Studies of Eating Disorders initiative between 1996 and 2002 [Kaye et al., 2000, 2004; Reba et al., 2005]. We tested 5,151 SNPs as well as the derived haplotypes from these SNPs for association to three progressively more restrictive phenotypic definitions of anorexia nervosa. We selected a total of 182 candidate genes that had been previously identified in case–control candidate gene association analyses, genes under linkage peaks for anorexia nervosa and bulimia nervosa [Devlin et al., 2002; Grice et al., 2002; Bulik et al., 2003; Bacanu et al., 2005], genes with evidence of expression in the brain, biologically plausible genes, and genes that were known to be estrogen responsive from microarray studies.
