The present investigation provides support for the use of fcMRI in clinical populations, including patients with compromised anatomical connectivity such as TAI. The results support the hypothesis that the hippocampus and frontal lobe circuits of patients with TAI have distinct patterns of interconnectedness and less connectivity with their contralateral homologue, as compared to healthy individuals. Additionally, the degree of bilateral connectivity in hippocampal circuits appears to correlate with patients’ memory-related outcome post-TAI.
