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Chunk #29 — Discussion

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The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall.
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An interesting finding in the present study was the different pattern of correlations between ReHo values in the DMN and memory function in normal older adults. In particular, AVLT-TR scores were positively correlated with regional coherence in the PCC/PCu and IPL, and negatively correlated with that in the PHG and MFG. Previous studies have also produced mixed results. For instance, He et al. (2007) found significant negative correlations between ReHo in the mPFC and Mini-Mental State Exam scores in patients with AD, but significant positive correlations between ReHo in the PCC/PCu and Mini-Mental State Exam scores. One explanation for these varied results is a functional dissociation of DMN components. Recently, it has been proposed that the DMN is not homogenous, as it has previously been considered (Uddin et al., 2009; Andrews-Hanna et al., 2010; Leech et al., 2011; Damoiseaux et al., 2012; Bado et al., 2014). Although the exact function and anatomy of distinct functional components is still unknown (e.g., anterior vs. posterior or ventral vs. dorsal), the notion of functional heterogeneity in the DMN and its dissociable roles during