SNP/indel associations with drug abuse at P<5×10−6 are presented from the AA-specific (Table S9), EA-specific (Table S10), and meta-analysis (Table S11) analyses. No SNPs or indels met genome-wide statistical significance in the EA-specific GWAS (Figure S2b) or the GWAS meta-analysis of both ancestry groups (Figure S2c). However, in the AA-specific GWAS, a genome-wide significant SNP association was observed for the rs9829896 SNP on chromosome 3 (P=4.63×10−8, Figure S2a). The rs9829896-C allele was associated with reduced risk of drug abuse: odds ratio (OR)=0.68 (Table 2). Rs9829896 is an intronic SNP in the gene encoding K(lysine) acetyltransferase 2B (KAT2B). Rs9829896 is in low to moderate linkage disequilibrium (r2<0.6 in the 1000 Genomes AFR panel) with nearby SNPs (Figure S3).
