Chunk #41 — II. Samples for genome studies of human addiction vulnerabilities and related phenotypes (Figure 2)

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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Of the 79 pedigrees from which family members made and kept appointments for study participation over this 30 month time period, 75% had African American probands and 69% had male probands. The sizes of the potentially-accessible sibships in the pedigrees of these individuals, as described by the probands, were: 1 (22%), 2 (23%), 3 (13%), 4 (11%), 5 (12%), 6 (9%), 7 (7%), 8 (1%), and 11 (2%). The numbers of accessible parents from these pedigrees was 0 (10%), 1 (28%) and 2 (62%). Average families for which more than the proband were accessible thus had 1.5 accessible parents and ca. 3.5 accessible sibs.