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Chunk #21 — Epigenetics and tolerance: MicroRNA mediates a selective degradation of BK isoforms leading to tolerance

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BK Channels: mediators and models for alcohol tolerance.
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the channel are minimized. Certainly, the evolutionary pressure leading to this strategy is of great interest. One can envision a range of possibilities, from adaptation as a means of protection from intoxicating levels of ingested alcohol from sources, such as rotted fruit, to the ‘hijacking’ of an adaptive mechanism normally invoked in response to other physiological or environmental ‘stressors’.