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Chunk #33 — DISCUSSION

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Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.
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In conclusion, we identified numerous novel GWS associations with OD. We found compelling evidence for association in several brain systems, most consistently for calcium and potassium signaling pathways, which should provide the impetus for further research on these brain systems in OD. Further, these findings are largely consonant with a set of SNP and pathway-based findings that are emerging for a broader range of neuropsychiatric traits, and as such, may bridge OD and other neuropsychiatric phenotypes.