and rs880395, which represent other distinct loci in this gene cluster produced similar results and confirmed the independent relationship of rs1996371 (p<0.005). Variants rs1996371 and rs922692 withstood the conservative Bonferroni correction (<0.005). Because most of the markers used in this study are highly correlated we also performed the less conservative correction of SNPs in LD with each other given by Nyholt et al [25]. This method provides the effective number of independent marker loci and in the present study this number was 5, giving an experiment-wide significance threshold of p<0.01. According to this less stringent criterion for correction, rs1996371, rs11634351, and rs922692 were significant after correction for multiple testing.
