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Chunk #13 — 2. Methods — 2.2 DNA Collection and Gentoyping

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Linkage scan of alcohol dependence in the UCSF Family Alcoholism Study.
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reduce errors, the probability that each genotype was correct was assessed using the error-checking algorithm implemented in MERLIN, and as suggested by the authors, genotypes that had a probability of less than 0.025 of being correct were removed from further consideration. (Abecasis et al., 2002). A total of 1867 problematic genotypes were identified and removed by MERLIN. Following these quality control procedures, a total of 1,269,708 genotypes were accepted with a success rate of 99.6%.