not take into account the differences in power to detect cis versus trans affects, thus the extreme nature of these fold changes may be inflated. While the average distance between correlated cis SNP and trait was 81Kb for CpG sites and 121Kb for mRNA transcripts when cis is defined as 1Mb, the peak enrichment of the number of significant cis QTLs was observed when the threshold distance for what is considered cis was set at ∼45bp for CpG sites and ∼68kb for mRNA transcripts (Figure 3).
