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Chunk #34 — DISCUSSION

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Association of substance dependence phenotypes in the COGA sample.
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the remaining abuse criteria (failure to fulfill role obligations and social/interpersonal problems) and craving are infrequently endorsed in the absence of co-occurring dependence criteria. This is particularly true in samples ascertained for substance use disorders, such as SAGE and COGA. For instance, in SAGE, of those who reported no alcohol dependence criteria, only 12-26 individuals endorsed at least one abuse criterion other than hazardous use (which was endorsed by 140). Hence, it is unlikely that the exclusion of abuse criteria resulted in our inability to capture a relevant portion of the liability continuum.