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Chunk #15 — Material and methods — Measures of spectral power and phase–amplitude coupling

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Subthalamic nucleus phase-amplitude coupling correlates with motor impairment in Parkinson's disease.
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Finally, we obtained the mean phase angle for the phase and amplitude frequency combination at which PAC was highest within the spectrum. We only considered the channel with the highest peak PAC per STN in order to avoid the introduction of additional phase lags for channels located further away from the PAC generation site. We tested whether the distribution of phase angles across subjects significantly different from a uniform distribution using a Rayleigh test.