and PRS were included as main effects to predict intercepts and slopes for male and female heavy episodic drinking (Table 2). For both sexes, close friend substance use prevalence strongly predicted a higher initial status of heavy episodic drinking and a greater rate of change in heavy episodic drinking between ages 15.5 to 21.5. For males specifically, PRS predicted a higher initial status of heavy episodic drinking and a greater rate of change in heavy episodic drinking between ages 15.5 to 21.5. The third and final model (Table 3) included the cross product between PRS and close friend substance use prevalence, while also accounting for their main effects and controlling for parental knowledge and school substance use prevalence. No significant interactions emerged between close friend substance use prevalence and PRS for either males or females for the heavy episodic drinking intercept and slopes.