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Chunk #80 — ONLINE METHODS: — Genetic correlations

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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
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International Cannabis Consortium and the Psychiatric Genomics Consortium, respectively. We conducted our own GWAS using the first release of the UKB data for five phenotypes: age first had sexual intercourse (n = 98,956), teenage conception among females (n = 40,077), use of sun protection (n = 111,560), household income (n = 97,059), and Townsend deprivation index score (n = 112,192). The sex-specific GWAS of general risk tolerance used to estimate the genetic correlation between males and females were conducted in the full release of UKB data, separately for males and females, following the same methodology and QC protocol as for our other GWAS in the full release of UKB data. The Supplementary Note and Supplementary Tables 9, 31 provide additional details. Also, the Supplementary Note, Supplementary Table 32, and Supplementary Fig. 15 report the results of proxy-phenotype analyses in which we examined whether the general-risk-tolerance lead SNPs tend to also be associated with related phenotypes.