Remarkably, activation of microglial P2Y12 and P2Y13 receptors following inflammation induces the release of paracrine mediators via upregulation of the P2Y1 and P2Y12 receptors on proliferated astroglia, and upon reduction of inflammation and microglia phenotype change, both P2Y12 and P2Y13 have shown to be downregulated on astrocytes.305
