As noted in the text, for some analysis we focused on the attempts that had >80% power to replicate the effect size found in Europeans. Statistical Power was calculated with the CaTS Power Calculator (www.sph.umich.edu/csg/abecasis/CaTS/) [42]. For each replication attempt we checked the power under a log-additive model to find the same effect size as in the discovery European GWAS, given the sample size of the replication GWAS and the allele frequency of the risk allele in East Asians. The number of expected replications was approached by multiplying the total number of replication attempts with the statistical power to replicate averaged for all attempts (see Table S5)
