Chunk #38 — 4. Selectively bred high alcohol-consuming rat lines and their phenotypic characteristics — 4.5. University of Chile B and University of Chile A rats
Behaviorally, UChB rats are less sensitive to the ataxic and hypothermic effects of ethanol, compared with UChA rats, with UChB rats also developing tolerance quicker than UChA rats to these ataxic effects (Tampier and Mardones, 1999; Tampier and Quintanilla, 2002b). In addition, similar to P rats (Stewart et al., 1991) UChB rats are less sensitive to the aversive effects of ethanol than UChA rats as measured by conditioned taste aversion (CTA: Quintanilla et al., 2001) and conditioned place aversion (CPA: Quintanilla and Tampier, 2011). A recent study has shown that chronic ethanol drinking by UChB rats leads to the development of tolerance to its CPA effects (Quintanilla and Tampier, 2011), which is similar to a previous study indicating chronic ethanol intake by UChB rats resulted in tolerance to the aversive effects of disulfiram (Tampier et al., 2008). Similar to P and sP rats, the UChB line of rats displays locomotor activation after low-dose ethanol, whereas the UChA line does not (Quintanilla, 1999). Although there is information on the effects of endogenous levels of, and exogenous treatments affecting, alcohol dehydrogenase, aldehyde
