To further examine these interesting results for locus 1 and locus 3, we show the number of heavy and light smokers in each joint genotype class, and corresponding odds ratios using the genotype that is homozygous for both reference (major) alleles as the reference group (Table 6). The reference alleles (major in HapMap CEU) are labeled “R” and the coded alleles (minor in HapMap CEU) are labeled “C”.