Chunk #14 — Results — Implicated genes highlight pathways and druggable targets

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Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.

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Using STRING32 to find proteins that interact with the proteins encoded by the high priority genes, we highlighted further druggable targets (Supplementary Table 19b). These included the PI3-kinase p110-delta subunit (part of the inositol phosphate metabolism pathway with INPP5E, which was implicated as a high-priority gene by rs10870202 in an intron of DNLZ, and a target for compounds in development for the treatment of COPD and asthma), and matrix metalloproteinases 1, 8 and 7 (targets for doxycycline, which is an antibiotic and anti-malarial).