SPECT scans using 123-labeled 5-iodo-A-85380 ([123I]5-IA) for two nonsmoking rare variant carriers (S1 with a nonsynonymous rare variant and S2 with two synonymous variants) compared to their age-matched nonsmoking controls.(A) α4β2 nAChR availability (VT/fP) in cortical regions (average of parietal, frontal, anterior cingulate, temporal and occipital cortices), striatum (average of caudate and putamen) and cerebellum in S1 and S2 compared to age-matched controls (CON).(B) Parametric images (α4β2 nAChR availability, VT/fP) of S1, a 30-year-old female healthy nonsmoker and an age- and sex-matched control). The color bar shows corresponding VT/fP values.
