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Chunk #24 — RESULTS — Effects of SDPS on alcohol taking and alcohol seeking — Extinction

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Stress vulnerability promotes an alcohol-prone phenotype in a preclinical model of sustained depression.
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Extinction training took place following re‐exposure to FR1 (Figure 5A). First, analysis of overall extinction performance during the whole training period revealed a significant time effect in absence of time × group interaction, repeated measures ANOVA, F EXT(5.74, 183.69) = 21.66, P < 0.001; F EXT × GROUP(11.48, 183.69) = 1.18, P = 0.302, as active responding decreased in all groups (Figure 5B). A significant main group effect was detected, repeated measures ANOVA, F GROUP(2, 32) = 7.21, P = 0.003), driven by increased responding of SDPS‐prone rats when compared with controls (P = 0.001) and their resilient counterparts (P = 0.026). No difference in responding between the latter two groups was observed (P = 0.229). To further dissect the temporal component of the observed variation in extinction performance between the three groups, active responding was analyzed in three bins of five extinction sessions, representing each week of training in‐between no‐training weekend days (Figure 5B). Repeated measures ANOVA showed significant time and group effects for the first two extinction bins. For EXT1 to 5, pairwise comparisons revealed that the main