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Chunk #22 — RESULTS — Genome-wide Association in Dutch Samples

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A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.
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The top results of the Australian sample (rs964170 for ND and rs12761801 for AD) were not replicated in the Dutch samples. In the Dutch analyses, the lowest p-values were 4.3×10−6 for ND (rs11631180 in TBC1D2B on chromosome 15), 2.3×10−7 for AD in NESDA sample (rs16882302 in BACH2 on chromosome 6) and 1.3×10−6 for AD in NTR sample (rs16953659 on chromosome 16) (see Tables S1-S3 in the Appendix). The results for ND show an association for rs2718771 and rs11771941 (p-values 4.87×10−5 and 4.99×10−5) which are both located in CNTNAP2 on chromosome 7. Interestingly, we also found a SNP (rs851712) in CNTNAP2 associated with AD in the NTR sample (p=2.61×10−6).