Chunk #27 — Semi-partial correlations — Simulation study 1

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A note on false positives and power in G × E modelling of twin data.

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Summarizing, Simulation study 1 shows that under the univariate moderation model, in which T1 is corrected for M1 only, and T2 is corrected for M2 only, the false positive rate can be (much) higher than the nominal α-level, especially if the correlation between T and M runs predominantly via E.