Chunk #14 — MATERIALS and METHODS — Discovery GWAS Analyses

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KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex.

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The GWAS resulted in λgc=1.036 for AAs (Figure S1a) and λgc=1.069 for EAs (Figure S1b). Given the slight λgc inflation in EAs, genomic control was applied to the EA-specific GWAS results prior to combining with the AA-specific GWAS results, resulting in λgc=1.020 for the multiancestry GWAS meta-analysis (Figure S1c). P<5×10−8 was used to declare genome-wide statistical significance.