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Chunk #25 — Results — Power to detect variants

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A map of human genome variation from population-scale sequencing.
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In summary, low coverage shotgun sequencing provided modest power for singletons in each sample (~25-40%), and very good power for variants seen 5 or more times in the samples sequenced. We estimate that there was approximately 95% power to find SNPs with 5% allele frequency in the sequenced samples, and nearly 90% power to find SNPs with 5% allele frequency in populations related by 1% divergence (Fig. 2b). Thus we believe the projects found almost all accessible common variation in the sequenced populations and the vast majority of common variants in closely related populations.