These findings suggest that BDNF may be a viable mechanism by which exercise exerts effects on mood [27]. Subsequent studies should identify the effect of both acute and regular exercise on pre- to post-exercise enhancement of BDNF as well as the effect on resting BDNF levels. Taken together, these data suggest that BDNF may be a primary mechanism of the antidepressant effects of exercise. However, future research is needed as it is likely that BDNF works in conjunction with (and is impacted by) several other signaling pathways.
