Chunk #18 — Methods and Materials — Meta-analysis

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Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use.

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We performed iterative conditional analysis using a partial correlation based score (PCBS) statistic(49), which can perform proper conditional analysis for meta-analysis that combines datasets measured using different arrays. PCBS takes GWAS meta-analysis summary statistics and LD estimated from the Haplotype Reference Consortium panel as input.