From ages 15 to 70 years, AUD was associated with a nearly 6-fold increase in all-cause mortality. This association is consistent with prior studies,4,15,16,21 although considerably stronger than that estimated from 2 recent meta-analyses: 3.38 (95% CI, 2.98–3.84) in men, 4.57 (95% CI, 3.86–5.42) in women,3 and 3.45 (95% CI, 2.96–4.02) in both sexes.2 Congruent with prior findings,3,14 the magnitude of this association varied substantially by age, being weakest in late adulthood.
