Participants from the Yale-Penn Study were recruited from 2000 to 2013. These participants were administered the Semi-Structured Assessment for Drug Dependence and Alcoholism30 to derive DSM-IV diagnoses of lifetime CAD and other major psychiatric traits. Data were collected for the SAGE trial from 1990 to 2007, and participants underwent phenotyping with the Semi-Structured Assessment for the Genetics of Alcoholism.31 Data were collected for the ICGHD from 2004 to 2009, and participants completed a comprehensive psychiatric diagnostic interview based on the Semi-Structured Assessment of the Genetics of Alcoholism–Australia.31 The method of phenotyping was similar across the 3 samples. Additional information about recruitment, genotyping, imputation, and quality control for the study cohorts is provided in eMethods in the Supplement.
