some evidence for replication, with support varying across outcomes. Consumption and Problems both showed nominal significance (p < 0.05) for a wide (pthreshold 0.01 to 0.5) and narrow range (pthreshold 0.01) of thresholds, respectively. The Maxdrinks PRS was robustly associated (p < 0.005) across a wide range of thresholds (pthreshold 0.05–0.5) Further details are provided in Table 3. Variance accounted for by the scores was low (<1%) for Consumption and Problems; for Maxdrinks scores accounted for >6% of the variance in some cases. Scores derived from the EUR-specific GWAS were similar though less pronounced (Supplementary Table 3).
