the contrary, using all variants, the variation explained was only 5% (SE=0.002) by using LDSC (Finucane et al., 2015), indicating that many variants with lower P-values were actually study-specific and including them in calculating PRS would introduce noise therefore lower their performance. Metal (Willer et al., 2010) was used for meta-analysis with the effect of each variant weighted by the sample sizes.
