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Chunk #21 — RESULTS — eQTL expression analysis

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Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity.
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To investigate which genes are likely to mediate phenotypic variation in high LD regions and to elucidate mediating brain tissue expression pathways, we performed eQTL analysis. A substantial percentage of eQTLs affect the expression of genes at a distance, often including variants close to a different gene in a different LD region (Ramasamy et al., 2014). Cis‐eQTLs are genetic variants within a 1 Mb region of a gene that explain variability in the expression of the gene in a target tissue (Gamazon et al., 2013; Gamazon et al., 2015; Lonsdale et al., 2013). We selected eQTLs from eight brain tissues from the GTEx database (Lonsdale et al., 2013). Cz alpha power associated p‐values resulted in inflated Q–Q plots for all tissues (Supporting Information Figure S3). Benjamini‐Hochberg FDR significant effects at q = .05 were observed for the Frontal Cortex and Anterior Cingulate Gyrus, and the Hypothalamus. Occipital alpha power showed similar effects, but for different brain regions (Caudate, Nucleus Accumbens, Hippocampus; Supporting Information Figure S4). The significant SNPs were frontal cortical tissue eQTLs for MTERF4, GNL3, and ITIH4; the latter