contrast the global connectivity, a measure of interrelationship among all the features within a biological network, demonstrated progressively weaker correlation (Fig. 1a). The discrepancy between strong overall expression and weaker connectivity suggests the neurobiology of alcohol dependence in PFC is due to altered co-variation of transcribed molecular features rather than discrete differential expression across the transcriptome. Average global connectivity per feature was significantly reduced in alcoholics (Fig. 1b), reflecting consistent homeostatic dysregulation for biological processes within alcohol-dependent PFC.
