was nominally associated (p = 9.67 × 10–5) in hippocampus but did not surpass the FDR < 0.05 threshold. RABEPK was not predicted to be differentially expressed by OA (best p = 0.055 in caudate).Table 1Fourteen gene-brain region combinations exhibiting predicted genetically driven differential gene expression in human brain regions associated with OA (across tissue FDR < 0.05) in analysis of gSEM GWAS summary statistics with S-PrediXcan analysis using GTEx version 8 eQTL gene models.GeneTissueAcross tissue FDROPRM1Cerebellum0.009SCAICerebellum0.009SCAIFrontal cortex0.009SCAIHippocampus0.009PPP6CHippocampus0.009PPP6CAnterior cingulate cortex0.01PPP6CCerebellar hemisphere0.01PPP6CPutamen basal ganglia0.01PPP6CCaudate basal ganglia0.01SCAICortex0.01PPP6CCortex0.01PPP6CFrontal cortex0.01PPP6CHypothalamus0.01PPP6CNucleus accumbens basal ganglia0.01
