At our university, we have considerable research expertise in the area of substance use and mental health. In the fall of 2011, we launched a university-wide research project focused on substance use and mental health. The scientific goal of the project is in-line with other on-going projects of faculty in this area: to understand how genetic and environmental factors impact the development of substance use and mental health problems. However, Spit for Science is unique in that we partnered from the beginning with campus administration and wellness practitioners to create a university-wide initiative aimed at benefitting our students and our local community.