the average χ2 statistic. Intercept is the estimated LD Score regression intercept. The ratio measures stratification bias, defined as (intercept − 1)/(mean χ2 − 1)ADHD attention-deficit/hyperactivity disorder; ALCP problematic alcohol use; CANN lifetime cannabis use; FSEX age at first sexual intercourse (reverse coded*); NSEX number of sexual partners; RISK risk tolerance; SMOK = lifetime tobacco initiation*Age at first sex was reverse coded so as to expect a positive relationship with EXT and EXT-minus-23andMe